WJEC GCSE Biology (3400)
GCSE Biology
Topic worksheet
Disease, defence and treatment
Original exam-style worksheet — not an official exam paper
Time guide: 50–60 minutes · Questions: 32 · Total marks: 104
Written in WJEC style. Answer in full sentences unless a calculation is required.
Answer all questions. Show working. Answers are in a separate file on the Worksheets page — do not look at them until you have finished.
1. State what is meant by a pathogen. [1]
2. State what is meant by a virus. [1]
3. State what is meant by a bacterium. [1]
4. State what is meant by a vaccine. [1]
5. State what is meant by herd immunity. [1]
6. State what is meant by an antibiotic. [1]
7. State what is meant by a white blood cell. [1]
8. State what is meant by phagocytosis. [1]
9. State what is meant by the first line of defence. [1]
10. State what is meant by a clinical trial. [1]
11. Owain is asked about a pathogen in a WJEC Biology paper.
(a) Describe a pathogen. [2]
(b) Explain why a pathogen is important in this topic. [3]
12. Owain is asked about a virus in a WJEC Biology paper.
(a) Describe a virus. [2]
(b) Explain why a virus is important in this topic. [3]
13. Owain is asked about a bacterium in a WJEC Biology paper.
(a) Describe a bacterium. [2]
(b) Explain why a bacterium is important in this topic. [3]
14. Owain is asked about a vaccine in a WJEC Biology paper.
(a) Describe a vaccine. [2]
(b) Explain why a vaccine is important in this topic. [3]
15. Owain is asked about herd immunity in a WJEC Biology paper.
(a) Describe herd immunity. [2]
(b) Explain why herd immunity is important in this topic. [3]
16. Owain is asked about an antibiotic in a WJEC Biology paper.
(a) Describe an antibiotic. [2]
(b) Explain why an antibiotic is important in this topic. [3]
17. A bacterium divides every 20 minutes. Starting from 1 cell, how many after 2 hours? [3]
18. A vaccine trial has 200 people. 6 have a serious side effect. Calculate the percentage. [3]
19. Antibody concentration rises from 2 units to 50 units. Calculate the percentage increase. [3]
20. A Petri dish colony count is 120 in 0.1 cm³. Estimate colonies in 5 cm³. [3]
21. An antibiotic zone of inhibition has diameter 26 mm. Calculate the area (π=3.14). [3]
22. A pathogen generation time is 30 minutes. How many generations in 5 hours? [3]
23. Owain carries out growing bacteria on agar using aseptic technique. This is a typical WJEC required-practical style question.
(a) Identify the independent variable and the dependent variable. [2]
(b) State one control variable and explain why it must be controlled. [2]
(c) Suggest one improvement or source of error and how it affects the result. [2]
24. Owain carries out testing the effectiveness of disinfectants. This is a typical WJEC required-practical style question.
(a) Identify the independent variable and the dependent variable. [2]
(b) State one control variable and explain why it must be controlled. [2]
(c) Suggest one improvement or source of error and how it affects the result. [2]
25. Owain carries out investigating the effect of antibiotics on bacterial growth. This is a typical WJEC required-practical style question.
(a) Identify the independent variable and the dependent variable. [2]
(b) State one control variable and explain why it must be controlled. [2]
(c) Suggest one improvement or source of error and how it affects the result. [2]
26. Owain carries out handwashing comparison with agar plates. This is a typical WJEC required-practical style question.
(a) Identify the independent variable and the dependent variable. [2]
(b) State one control variable and explain why it must be controlled. [2]
(c) Suggest one improvement or source of error and how it affects the result. [2]
27. Compare antibiotics with painkillers. [4]
28. Compare active immunity with passive immunity. [4]
29. Compare bacteria with viruses. [4]
30. Compare preclinical testing with clinical testing. [4]
31. Apply your knowledge of a white blood cell to this situation: complementary shape to the antigen [3]
32. Apply your knowledge of phagocytosis to this situation: works against many pathogens [3]